Mitogen-activated protein kinase kinase 4

URI: https://gptkb.org/entity/Mitogen-activated_protein_kinase_kinase_4
GPTKB entity
Statements (40)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activatedBy gptkb:JNK
gptkb:p38_MAPK
gptkbp:alternativeName gptkb:MKK4
gptkb:JNKK1
gptkbp:associatedWith gptkb:cancer
pancreatic cancer
gptkbp:biologicalProcess protein serine/threonine kinase activity
gptkbp:Entrez_Gene_ID 6416
gptkbp:enzymeCommissionNumber 2.7.12.2
gptkbp:expressedIn many tissues
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function signal transduction
phosphorylation
kinase activity
gptkbp:gene gptkb:MAP2K4
gptkbp:HGNC_ID 6840
https://www.w3.org/2000/01/rdf-schema#label Mitogen-activated protein kinase kinase 4
gptkbp:involves apoptosis
cellular stress response
inflammatory response
gptkbp:length 399
gptkbp:locatedOnChromosome 17p11.2
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:OMIM 602753
gptkbp:part_of_pathway gptkb:MAPK_signaling_pathway
gptkbp:PDB 3ALO
gptkbp:phosphorylates gptkb:MAPK9
gptkb:MAPK14
gptkb:MAPK8
gptkbp:RefSeq NM_003010
gptkbp:regulates cell differentiation
cell proliferation
cell survival
cell migration
gptkbp:UniProtID gptkb:P45985
gptkbp:bfsParent gptkb:MKK4
gptkbp:bfsLayer 7