|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:MKK4
gptkb:MAP2K4
gptkb:MEK4
|
|
gptkbp:associatedWith
|
gptkb:cancer
pancreatic cancer
|
|
gptkbp:biologicalProcess
|
signal transduction
apoptotic process
protein kinase activity
cellular response to stress
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
Kyriakis JM
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:MAP2K4
|
|
gptkbp:Entrez_Gene_ID
|
6416
|
|
gptkbp:enzymeClassification
|
gptkb:EC_2.7.12.2
|
|
gptkbp:expressedIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:function
|
dual specificity protein kinase
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6840
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JNKK1
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
17
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
|
|
gptkbp:OMIM
|
600982
|
|
gptkbp:orthologIn
|
Map2k4 (mouse)
Map2k4 (rat)
|
|
gptkbp:PDB
|
gptkb:3ALN
3ALO
|
|
gptkbp:phosphorylates
|
gptkb:TAK1
gptkb:JNK
gptkb:MAP3K1
gptkb:p38_MAPK
ASK1
|
|
gptkbp:RefSeq
|
NM_003010
|
|
gptkbp:regulates
|
gptkb:MAPK10
gptkb:MAPK9
gptkb:MAPK8
apoptosis
cell proliferation
stress response
|
|
gptkbp:UniProtID
|
gptkb:P45985
|
|
gptkbp:bfsParent
|
gptkb:MAP2K4
gptkb:MAP2K4_gene
gptkb:Mitogen-activated_protein_kinase_kinase_4
|
|
gptkbp:bfsLayer
|
8
|