c-Jun N-terminal kinase pathway

GPTKB entity

Predicate	Object
gptkbp:instanceOf	signaling molecule
gptkbp:activatedBy	stress cytokines inflammatory signals UV irradiation
gptkbp:alsoKnownAs	gptkb:JNK_pathway
gptkbp:discoveredIn	1990s
gptkbp:downstreamOf	gptkb:AP-1_transcription_factor gptkb:Fos_family_proteins gptkb:Jun_family_proteins
gptkbp:dysregulationAssociatedWith	gptkb:cancer gptkb:diabetes neurodegenerative diseases inflammatory diseases
gptkbp:foundIn	eukaryotes
https://www.w3.org/2000/01/rdf-schema#label	c-Jun N-terminal kinase pathway
gptkbp:inhibitedBy	gptkb:SP600125 gptkb:JNK-IN-8
gptkbp:involves	gptkb:MAPK10 gptkb:MAPK9 gptkb:MAPK8 gptkb:c-Jun_N-terminal_kinases
gptkbp:partOf	gptkb:mitogen-activated_protein_kinase_pathways
gptkbp:phosphorylates	gptkb:Bcl-2 gptkb:ATF2 gptkb:Elk-1 gptkb:c-Jun gptkb:p53
gptkbp:regulates	apoptosis cell differentiation cell proliferation cell survival gene expression
gptkbp:relatedTo	gptkb:ERK_pathway gptkb:p38_MAPK_pathway
gptkbp:studiedIn	gptkb:Mus_musculus gptkb:Homo_sapiens gptkb:Drosophila_melanogaster
gptkbp:upregulatedBy	gptkb:TAK1 gptkb:MAP2K4 gptkb:MAP2K7 gptkb:MAP3K1
gptkbp:bfsParent	gptkb:JNK_pathway
gptkbp:bfsLayer	6