|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:MEKK1
gptkb:MAPK/ERK_kinase_kinase_1
gptkb:MAPKKK1
|
|
gptkbp:discoveredBy
|
Kyriakis JM et al.
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000132912
4214
|
|
gptkbp:expressedIn
|
gptkb:testis
brain
heart
liver
various tissues
|
|
gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase_kinase_kinase_1
|
|
gptkbp:function
|
gptkb:MAPK_signaling_pathway
serine/threonine protein kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
GO:0000165
GO:0004709
|
|
gptkbp:HGNC_ID
|
6840
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP3K1
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:TAK1
gptkb:CDC42
gptkb:RAC1
gptkb:TAB1
gptkb:TAB2
gptkb:MAPK8IP1
gptkb:MAPK8IP2
gptkb:MAPK8IP3
gptkb:TRAF2
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:length
|
1,507 amino acids
|
|
gptkbp:locatedOnChromosome
|
5
|
|
gptkbp:location
|
gptkb:5q11.2
|
|
gptkbp:molecularWeight
|
164 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:46,XY_sex_reversal
esophageal squamous cell carcinoma
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:2CLQ
3F60
|
|
gptkbp:phosphorylates
|
gptkb:MAP2K1
gptkb:MAP2K4
gptkb:MAP2K7
gptkb:MAP2K2
|
|
gptkbp:regulates
|
gptkb:ERK_pathway
gptkb:JNK_pathway
gptkb:p38_MAPK_pathway
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q13233
|
|
gptkbp:bfsParent
|
gptkb:MAPK_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|