|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:MAP2K4
gptkb:Mitogen-activated_protein_kinase_kinase_4
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
prostate cancer
|
|
gptkbp:biologicalProcess
|
apoptosis
cell differentiation
cell proliferation
protein serine/threonine kinase activity
stress-activated protein kinase signaling cascade
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodedBy
|
gptkb:MAP2K4_gene
|
|
gptkbp:Entrez_Gene_ID
|
6416
|
|
gptkbp:enzymeClassification
|
gptkb:EC_2.7.12.2
|
|
gptkbp:function
|
phosphorylates and activates JNK and p38 MAP kinases
|
|
gptkbp:HGNC_ID
|
6840
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MKK4
|
|
gptkbp:inhibitedBy
|
gptkb:SB203580
gptkb:SP600125
|
|
gptkbp:interactsWith
|
gptkb:TAK1
gptkb:JNK1
gptkb:JNK2
gptkb:MAP3K1
gptkb:JNK3
gptkb:MAP3K2
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17q11.2
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:JNK_signaling_pathway
gptkb:p38_MAPK_pathway
|
|
gptkbp:PDB
|
3ALO
|
|
gptkbp:phosphorylates
|
gptkb:Ser257
gptkb:Thr261
|
|
gptkbp:RefSeq
|
gptkb:NP_003006.2
|
|
gptkbp:regulates
|
activated by phosphorylation
apoptotic process
inflammatory response
cellular response to stress
|
|
gptkbp:substrate
|
gptkb:JNK
gptkb:p38_MAPK
|
|
gptkbp:UniProtID
|
gptkb:P45985
|
|
gptkbp:bfsParent
|
gptkb:JNK_pathway
|
|
gptkbp:bfsLayer
|
6
|