Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:alternativeName |
gptkb:MAP2K4
gptkb:Mitogen-activated_protein_kinase_kinase_4 gptkb:JNKK1 SEK1 |
| gptkbp:associatedWith |
gptkb:cancer
pancreatic cancer |
| gptkbp:biologicalProcess |
cell differentiation
apoptosis regulation protein serine/threonine kinase activity stress-activated protein kinase signaling cascade |
| gptkbp:EC_number |
2.7.12.2
|
| gptkbp:encodedBy |
gptkb:MAP2K4_gene
|
| gptkbp:function |
phosphorylates and activates JNK and p38 MAP kinases
|
| https://www.w3.org/2000/01/rdf-schema#label |
MEK4
|
| gptkbp:inhibitedBy |
GSK-212
JNJ-7706621 |
| gptkbp:locatedOnChromosome |
17p11.2
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:pathway |
gptkb:JNK_signaling_pathway
gptkb:MAPK_signaling_pathway gptkb:p38_MAPK_pathway |
| gptkbp:phosphorylates |
MAPK14 (p38α)
MAPK8 (JNK1) MAPK9 (JNK2) |
| gptkbp:species |
gptkb:human
gptkb:mouse right |
| gptkbp:UniProtID |
gptkb:P45985
|
| gptkbp:bfsParent |
gptkb:MAP2K4
gptkb:BIX02189 |
| gptkbp:bfsLayer |
8
|