|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:MAP2K4
gptkb:MAP2K7
|
|
gptkbp:alsoKnownAs
|
gptkb:JNK3
gptkb:PRKM10
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:component
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
gptkb:Davis_RJ_group
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:encodes
|
gptkb:MAPK10_protein
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000107643
5602
|
|
gptkbp:expressedIn
|
brain
neurons
|
|
gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase_10
|
|
gptkbp:function
|
signal transduction
protein serine/threonine kinase activity
response to stress
regulation of neuronal apoptosis
|
|
gptkbp:GOProcess
|
regulation of transcription, DNA-templated
|
|
gptkbp:hasKinaseDomain
|
yes
|
|
gptkbp:HGNC_ID
|
6882
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPK10
|
|
gptkbp:inhibitedBy
|
gptkb:SP600125
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
apoptosis
neuronal development
|
|
gptkbp:length
|
464 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:JNK_subfamily
|
|
gptkbp:molecularWeight
|
53 kDa
|
|
gptkbp:mutationAssociatedWith
|
neurodegenerative diseases
|
|
gptkbp:OMIM
|
602896
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
3E7O
|
|
gptkbp:phosphorylates
|
gptkb:ATF2
gptkb:c-Jun
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:regulates
|
gptkb:synaptic_plasticity
neuronal cell death
|
|
gptkbp:relatedTo
|
gptkb:MAPK9
gptkb:MAPK8
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
gptkb:P53779
|
|
gptkbp:bfsParent
|
gptkb:JNK_pathway
|
|
gptkbp:bfsLayer
|
6
|