MAP kinase kinase (MAP2K)

URI: https://gptkb.org/entity/MAP_kinase_kinase_(MAP2K)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:activatedBy	gptkb:MAP_kinase_(MAPK) gptkb:MAP_kinase_kinase_kinase_(MAP3K)
gptkbp:alsoKnownAs	gptkb:MEK gptkb:MAP2K
gptkbp:associatedWith	gptkb:cardiofaciocutaneous_syndrome gptkb:cancer gptkb:Noonan_syndrome
gptkbp:biologicalProcess	protein serine/threonine kinase activity
gptkbp:enzymeClassification	gptkb:EC_2.7.12.2
gptkbp:foundIn	eukaryotes
gptkbp:function	phosphorylates MAP kinases
gptkbp:GO_term	gptkb:GO:0004707
gptkbp:hasMember	gptkb:MAP2K1 gptkb:MAP2K3 gptkb:MAP2K6 gptkb:MAP2K4 gptkb:MAP2K7 gptkb:MAP2K2 gptkb:MAP2K5
https://www.w3.org/2000/01/rdf-schema#label	MAP kinase kinase (MAP2K)
gptkbp:inhibitedBy	gptkb:MEK_inhibitors
gptkbp:partOf	gptkb:MAPK_signaling_pathway
gptkbp:pathway	gptkb:ERK_pathway gptkb:JNK_pathway gptkb:p38_MAPK_pathway
gptkbp:phosphorylates	gptkb:JNK gptkb:p38_MAPK gptkb:ERK
gptkbp:regulates	phosphorylation protein-protein interaction sumoylation ubiquitination
gptkbp:role	apoptosis cell differentiation cell proliferation oncogenesis stress response
gptkbp:subcellularLocation	gptkb:nucleus gptkb:cytoplasm
gptkbp:UniProtID	O14733 (MAP2K7) P36507 (MAP2K2) P45985 (MAP2K4) P46734 (MAP2K1) P52564 (MAP2K6) Q02750 (MAP2K3) Q13163 (MAP2K5)
gptkbp:bfsParent	gptkb:mitogen-activated_protein_kinase
gptkbp:bfsLayer	6