|
gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:activatedBy
|
gptkb:ATF2
gptkb:Elk-1
gptkb:c-Jun
gptkb:p53
cytokines
UV radiation
stress signals
reactive oxygen species
|
|
gptkbp:alsoKnownAs
|
gptkb:c-Jun_N-terminal_kinase_pathway
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:downstreamOf
|
gptkb:Bcl-2_family_proteins
gptkb:AP-1_complex
transcription factors
|
|
gptkbp:foundIn
|
eukaryotic cells
|
|
gptkbp:hasComponent
|
gptkb:JNK1
gptkb:JNK2
gptkb:JNK3
|
|
gptkbp:hasRole
|
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
liver diseases
inflammation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JNK signaling pathway
|
|
gptkbp:inhibitedBy
|
gptkb:SP600125
gptkb:JNK-IN-8
|
|
gptkbp:involves
|
gptkb:JNK_proteins
gptkb:MAPK10
gptkb:MAPK9
gptkb:MAPK8
|
|
gptkbp:modulatedBy
|
cell survival
gene expression
immune response
cell death
|
|
gptkbp:partOf
|
MAPK signaling pathways
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
inflammatory response
|
|
gptkbp:relatedTo
|
gptkb:p38_MAPK_pathway
gptkb:ERK_signaling_pathway
|
|
gptkbp:studiedIn
|
mouse models
cell culture
|
|
gptkbp:target
|
small molecule inhibitors
therapeutic drugs
|
|
gptkbp:upregulatedBy
|
gptkb:MAP2K4
gptkb:MAP2K7
|
|
gptkbp:bfsParent
|
gptkb:MKK4
gptkb:DUSP22
gptkb:DLK
gptkb:AP1
gptkb:TNF
gptkb:MAP4K1
|
|
gptkbp:bfsLayer
|
7
|