|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
stress
cytokines
inflammatory signals
UV irradiation
|
|
gptkbp:alsoKnownAs
|
gptkb:MAPK8
|
|
gptkbp:encodedBy
|
gptkb:MAPK8_gene
|
|
gptkbp:Entrez_Gene_ID
|
5599
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.24
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart
liver
|
|
gptkbp:function
|
apoptosis
cell differentiation
cell proliferation
signal transduction
regulation of gene expression
serine/threonine kinase
|
|
gptkbp:gene
|
gptkb:MAPK8
|
|
gptkbp:GO
|
gptkb:GO:0004707
|
|
gptkbp:hasIsoform
|
gptkb:JNK1α1
gptkb:JNK1α2
gptkb:JNK1β1
gptkb:JNK1β2
|
|
gptkbp:HGNC_ID
|
6881
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JNK1
|
|
gptkbp:involvedIn
|
gptkb:cancer
gptkb:MAPK_signaling_pathway
neurodegenerative diseases
immune response
cellular response to stress
apoptosis pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10q11.22
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:c-Jun_N-terminal_kinases
|
|
gptkbp:molecularWeight
|
48 kDa
|
|
gptkbp:OMIM
|
601158
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:4AWI
gptkb:4QTD
3ELJ
|
|
gptkbp:phosphorylates
|
gptkb:ATF2
gptkb:c-Jun
|
|
gptkbp:RefSeq
|
gptkb:NM_002750
|
|
gptkbp:regulates
|
apoptosis
transcription factors
cell cycle
|
|
gptkbp:structure
|
contains protein kinase domain
|
|
gptkbp:UniProtID
|
gptkb:P45983
|
|
gptkbp:bfsParent
|
gptkb:P42680
gptkb:MAPK_signaling_pathway
gptkb:mitogen-activated_protein_kinase
|
|
gptkbp:bfsLayer
|
6
|