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gptkbp:instanceOf
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gptkb:protein
gptkb:gene
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gptkbp:alsoKnownAs
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MLK2
Mitogen-activated protein kinase kinase kinase 10
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|
gptkbp:component
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gptkb:nucleus
gptkb:cytoplasm
|
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gptkbp:discoveredBy
|
Dorow et al.
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|
gptkbp:discoveredIn
|
1993
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gptkbp:domain
|
SH3 domain
protein kinase domain
leucine zipper domain
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gptkbp:encodedBy
|
MAP3K10 gene
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|
gptkbp:Entrez_Gene_ID
|
ENSG00000105287
4293
|
|
gptkbp:expressedIn
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gptkb:testis
brain
various tissues
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|
gptkbp:family
|
STE protein kinase family
|
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gptkbp:function
|
gptkb:MAPK_signaling_pathway
protein kinase activity
serine/threonine protein kinase activity
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gptkbp:geneType
|
protein-coding
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gptkbp:GOProcess
|
signal transduction
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP3K10
|
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gptkbp:interactsWith
|
gptkb:MAP2K4
gptkb:MAP2K7
gptkb:CDC42
gptkb:RAC1
gptkb:MAPK8IP1
gptkb:MAPK8IP2
|
|
gptkbp:involvedIn
|
gptkb:JNK_signaling_pathway
apoptosis
neuronal signaling
|
|
gptkbp:length
|
1600 amino acids
|
|
gptkbp:locatedOnChromosome
|
19q13.2
|
|
gptkbp:molecularWeight
|
163 kDa
|
|
gptkbp:mutationAssociatedWith
|
neurological disorders
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:phosphorylates
|
gptkb:MAPK10
gptkb:MAPK9
gptkb:MAP2K4
gptkb:MAP2K7
gptkb:MAPK8
|
|
gptkbp:RefSeq
|
NM_002448
|
|
gptkbp:regulates
|
neurite outgrowth
cell death
stress response
|
|
gptkbp:subfamily
|
Mixed lineage kinase (MLK) subfamily
|
|
gptkbp:UniProtID
|
Q02779
|
|
gptkbp:bfsParent
|
gptkb:MAP2K3
|
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gptkbp:bfsLayer
|
7
|