|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
MAPKKK3
MEKK3
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
inflammatory diseases
vascular malformations
|
|
gptkbp:discoveredBy
|
1996
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000108984
4215
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
Mitogen-activated protein kinase kinase kinase 3
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell proliferation
inflammatory response
serine/threonine protein kinase activity
involved in MAPK signaling pathway
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:MAP3K3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP3K3
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:AKT1
gptkb:TAK1
gptkb:TRAF6
gptkb:TAB1
gptkb:NIK
|
|
gptkbp:locatedOnChromosome
|
17
|
|
gptkbp:location
|
gptkb:17q23.3
|
|
gptkbp:molecularWeight
|
~70 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Map3k3
|
|
gptkbp:pathway
|
gptkb:Toll-like_receptor_signaling_pathway
gptkb:NF-kappaB_signaling_pathway
MAPK cascade
|
|
gptkbp:phosphorylates
|
gptkb:MAP2K6
gptkb:MAP2K4
gptkb:MAP2K5
IKBKB
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:proteinFamily
|
STE protein kinase family
|
|
gptkbp:regulates
|
angiogenesis
cell migration
immune response
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q99759
|
|
gptkbp:bfsParent
|
gptkb:MAP2K3
|
|
gptkbp:bfsLayer
|
7
|