|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
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gptkb:NIK
|
|
gptkbp:associatedWith
|
immune response
lymphoid organ development
|
|
gptkbp:component
|
GO:0005737 (cytoplasm)
|
|
gptkbp:discoveredBy
|
Malinin et al., 1997
|
|
gptkbp:encodes
|
Mitogen-activated protein kinase kinase kinase 14
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000141564
9020
|
|
gptkbp:expressedIn
|
lymphoid tissues
|
|
gptkbp:function
|
serine/threonine protein kinase activity
GO:0004709 (MAP kinase kinase kinase activity)
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
|
|
gptkbp:HGNC_ID
|
HGNC:6850
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP3K14
|
|
gptkbp:inhibitedBy
|
AM-0216
NIK SMI1
|
|
gptkbp:interactsWith
|
gptkb:TRAF2
TRAF3
BIRC2
BIRC3
|
|
gptkbp:involvedIn
|
gptkb:NF-kappaB_signaling_pathway
|
|
gptkbp:length
|
947 amino acids
|
|
gptkbp:locatedOnChromosome
|
17q21.31
|
|
gptkbp:molecularWeight
|
110 kDa
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
|
|
gptkbp:OMIM
|
604684
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Map3k14
|
|
gptkbp:pathway
|
KEGG: hsa04064 (NF-kappa B signaling pathway)
Reactome: R-HSA-209560 (Non-canonical NF-kappaB pathway)
|
|
gptkbp:phosphorylates
|
IKK-alpha
NFKB2/p100
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:proteinFamily
|
protein kinase domain
N-terminal regulatory domain
MAP kinase kinase kinase family
|
|
gptkbp:referenceGenome
|
NM_003954
|
|
gptkbp:referenceProteinSequence
|
NP_003945
|
|
gptkbp:regulates
|
ubiquitination
proteasomal degradation
non-canonical NF-kappaB pathway
|
|
gptkbp:species
|
gptkb:human
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q99558
|
|
gptkbp:bfsParent
|
gptkb:MAP2K3
|
|
gptkbp:bfsLayer
|
7
|