|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
MLK3
Mixed-lineage kinase 3
|
|
gptkbp:discoveredBy
|
Manning et al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodes
|
Mitogen-activated protein kinase kinase kinase 11
|
|
gptkbp:Entrez_Gene_ID
|
4296
ENSG00000111652
|
|
gptkbp:expressedIn
|
gptkb:kidney
gptkb:testis
brain
heart
liver
|
|
gptkbp:function
|
serine/threonine protein kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6841
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP3K11
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:TAK1
gptkb:CDC42
gptkb:RAC1
gptkb:JIP1
JIP2
JIP3
JIP4
|
|
gptkbp:involvedIn
|
gptkb:JNK_signaling_pathway
gptkb:MAPK_signaling_pathway
|
|
gptkbp:length
|
847
|
|
gptkbp:locatedOnChromosome
|
chromosome 11
|
|
gptkbp:molecularWeight
|
97 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Map3k11
|
|
gptkbp:phosphorylates
|
gptkb:MAPK10
gptkb:MAPK9
gptkb:MAP2K4
gptkb:MAP2K7
gptkb:MAPK8
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q16584
|
|
gptkbp:bfsParent
|
gptkb:MAP2K3
|
|
gptkbp:bfsLayer
|
7
|