|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:TNF-alpha
oxidative stress
|
|
gptkbp:alternativeName
|
ASK1
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:component
|
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
Ichijo et al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodes
|
Mitogen-activated protein kinase kinase kinase 5
|
|
gptkbp:Entrez_Gene_ID
|
4217
ENSG00000135341
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
protein serine/threonine kinase activity
serine/threonine protein kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
apoptotic process
|
|
gptkbp:HGNC_ID
|
6840
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP3K5
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:TRAF6
gptkb:TRAF2
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
apoptosis
|
|
gptkbp:KEGGID
|
hsa:4217
|
|
gptkbp:length
|
1374 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
6q22.33
|
|
gptkbp:molecularWeight
|
approximately 170 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:diabetes
cardiomyopathy
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Map3k5
|
|
gptkbp:PDB
|
3A7O
|
|
gptkbp:phosphorylates
|
gptkb:MAP2K6
gptkb:MAP2K4
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:JNK_pathway
gptkb:p38_MAPK_pathway
activated by dissociation from 14-3-3
inhibited by 14-3-3 binding
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q99683
|
|
gptkbp:bfsParent
|
gptkb:MAP2K3
|
|
gptkbp:bfsLayer
|
7
|