|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BTEB3
gptkb:EZF
gptkb:GKLF
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:glioblastoma
colorectal cancer
skin diseases
|
|
gptkbp:discoveredBy
|
gptkb:Yoshinori_Nagai
|
|
gptkbp:domain
|
zinc finger domain
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000136826
9314
|
|
gptkbp:expressedIn
|
gptkb:skin
cornea
intestine
epithelial cells
|
|
gptkbp:firstDescribed
|
1996
|
|
gptkbp:fullName
|
gptkb:Kruppel-like_factor_4
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell proliferation
transcription factor
regulation of differentiation
maintenance of stem cell pluripotency
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6348
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KLF4
|
|
gptkbp:interactsWith
|
gptkb:OCT4
gptkb:SOX2
gptkb:c-MYC
|
|
gptkbp:isTranscriptionFactorFor
|
cell cycle genes
pluripotency genes
differentiation genes
|
|
gptkbp:length
|
513
|
|
gptkbp:locatedOnChromosome
|
9
9q31
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:OMIM
|
602253
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Klf4
|
|
gptkbp:orthologInZebrafish
|
gptkb:klf4a
klf4b
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:proteinFamily
|
gptkb:Kruppel-like_factors
|
|
gptkbp:regulates
|
gptkb:p21
gptkb:Notch_signaling_pathway
gptkb:p53
gptkb:TGF-beta
gptkb:Wnt_signaling
gptkb:E-cadherin
microRNAs
|
|
gptkbp:role
|
induced pluripotent stem cell generation
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:transcriptionRegulationType
|
activator
repressor
|
|
gptkbp:UniProtID
|
O43474
|
|
gptkbp:bfsParent
|
gptkb:NANOG
gptkb:miR-145
gptkb:Sp/KLF_transcription_factor_family
gptkb:human_induced_pluripotent_stem_cells
gptkb:EWSR1
gptkb:AP-2
gptkb:KLF4_gene
gptkb:Kruppel-like_factor_4
gptkb:Kruppel-like_factors
gptkb:Nanog
gptkb:POU5F1
gptkb:SRY-box_transcription_factor_2
|
|
gptkbp:bfsLayer
|
7
|