human induced pluripotent stem cells

URI: https://gptkb.org/entity/human_induced_pluripotent_stem_cells
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf Cell
gptkbp:abbreviation gptkb:hiPSCs
gptkbp:can_be_differentiated_into gptkb:hepatocytes
neurons
pancreatic beta cells
cardiomyocytes
gptkbp:can_be_genome_edited_by gptkb:CRISPR-Cas9
gptkbp:can_be_patient-specific true
gptkbp:capable_of differentiation into all three germ layers
gptkbp:derivedFrom human somatic cells
gptkbp:discoveredBy gptkb:Shinya_Yamanaka
2007
gptkbp:ethical_advantage_over human embryonic stem cells
gptkbp:expressedIn pluripotency markers
gptkbp:form teratomas in vivo
https://www.w3.org/2000/01/rdf-schema#label human induced pluripotent stem cells
gptkbp:reprogrammed_by transcription factors
gptkbp:reprogramming_factors gptkb:KLF4
gptkb:OCT4
gptkb:SOX2
gptkb:c-MYC
gptkbp:similarTo human embryonic stem cells
gptkbp:storage stem cell banks
gptkbp:studiedBy cellular reprogramming research
gptkbp:subject gptkb:Nobel_Prize_in_Physiology_or_Medicine_2012
gptkbp:used_in drug discovery
regenerative medicine
disease modeling
toxicology testing
cell therapy research
gptkbp:usedFor personalized medicine
gptkbp:bfsParent gptkb:Allen_Cell_Explorer
gptkbp:bfsLayer 6