Kruppel-like factor 4

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
transcription factor
gptkbp:alias gptkb:EZF
gptkb:GKLF
gptkbp:associatedWith gptkb:cancer
colorectal cancer
skin diseases
gastric cancer
gptkbp:discoveredBy 1996
gptkbp:encodedBy gptkb:KLF4_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000136826
9314
gptkbp:expressedIn gptkb:cancer
gptkb:skin
cornea
intestine
epithelial tissues
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function regulation of apoptosis
regulation of cell proliferation
regulation of differentiation
maintenance of stem cell pluripotency
gptkbp:gene gptkb:KLF4
gptkbp:HGNC_ID gptkb:HGNC:6348
https://www.w3.org/2000/01/rdf-schema#label Kruppel-like factor 4
gptkbp:interactsWith gptkb:c-Myc
gptkb:p53
gptkb:STAT3
gptkb:TGF-beta
gptkb:beta-catenin
gptkbp:locatedOnChromosome gptkb:chromosome_9q31
gptkbp:location gptkb:nucleus
gptkbp:member gptkb:Kruppel-like_factor_family
gptkbp:OMIM 602253
gptkbp:PDB gptkb:2WBU
gptkbp:regulates gptkb:p21
gptkb:OCT4
gptkb:SOX2
gptkb:E-cadherin
gptkb:Nanog
wound healing
inflammation
cell cycle
DNA damage response
epithelial-mesenchymal transition
gptkbp:role tumor suppression
oncogenesis
induced pluripotent stem cell generation
gptkbp:UniProtID O43474
gptkbp:bfsParent gptkb:Klf4
gptkbp:bfsLayer 6