|
gptkbp:instanceOf
|
gptkb:transcription_factor
gptkb:protein
|
|
gptkbp:alias
|
gptkb:EZF
gptkb:GKLF
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
skin diseases
gastric cancer
|
|
gptkbp:discoveredBy
|
1996
|
|
gptkbp:encodedBy
|
gptkb:KLF4_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000136826
9314
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skin
cornea
intestine
epithelial tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell proliferation
regulation of differentiation
maintenance of stem cell pluripotency
|
|
gptkbp:gene
|
gptkb:KLF4
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6348
|
|
gptkbp:interactsWith
|
gptkb:c-Myc
gptkb:p53
gptkb:STAT3
gptkb:TGF-beta
gptkb:beta-catenin
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9q31
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:member
|
gptkb:Kruppel-like_factor_family
|
|
gptkbp:OMIM
|
602253
|
|
gptkbp:PDB
|
gptkb:2WBU
|
|
gptkbp:regulates
|
gptkb:p21
gptkb:OCT4
gptkb:SOX2
gptkb:E-cadherin
gptkb:Nanog
wound healing
inflammation
cell cycle
DNA damage response
epithelial-mesenchymal transition
|
|
gptkbp:role
|
tumor suppression
oncogenesis
induced pluripotent stem cell generation
|
|
gptkbp:UniProtID
|
O43474
|
|
gptkbp:bfsParent
|
gptkb:Klf4
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Kruppel-like factor 4
|