|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:MYC
gptkb:bHLHe39
v-myc avian myelocytomatosis viral oncogene homolog
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:domain
|
basic helix-loop-helix leucine zipper (bHLH-LZ)
|
|
gptkbp:encodedBy
|
gptkb:MYC_gene
|
|
gptkbp:Entrez_Gene_ID
|
4609
ENSG00000136997
|
|
gptkbp:formsHeterodimerWith
|
gptkb:MAX
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:HGNC_ID
|
7553
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-MYC
|
|
gptkbp:involvedIn
|
gptkb:neuroblastoma
gptkb:Burkitt_lymphoma
gptkb:cancer
colorectal cancer
leukemia
prostate cancer
hepatocellular carcinoma
|
|
gptkbp:length
|
439 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 8
8q24.21
|
|
gptkbp:molecularWeight
|
49 kDa
|
|
gptkbp:OMIM
|
190080
|
|
gptkbp:overexpressedIn
|
tumorigenesis
|
|
gptkbp:phosphorylates
|
gptkb:Ser62
Thr58
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
metabolism
cellular senescence
angiogenesis
cell growth
DNA replication
cell cycle
chromatin structure
cell adhesion
ribosome biogenesis
microRNA expression
stem cell self-renewal
histone acetylation
|
|
gptkbp:target
|
gptkb:siRNA
antisense oligonucleotides
small molecule inhibitors
|
|
gptkbp:translocationPartner
|
t(2;8)(p12;q24)
t(8;14)(q24;q32)
t(8;22)(q24;q11)
|
|
gptkbp:UniProtID
|
P01106
|
|
gptkbp:bfsParent
|
gptkb:TCF/LEF
gptkb:TCF/LEF_transcription_factors
gptkb:human_induced_pluripotent_stem_cells
gptkb:POU5F1
gptkb:SRY-box_transcription_factor_2
|
|
gptkbp:bfsLayer
|
7
|