|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:CDH1
gptkb:cadherin-1
|
|
gptkbp:calciumDependent
|
true
|
|
gptkbp:cytoplasmicDomainBinds
|
catenins
|
|
gptkbp:discoveredBy
|
gptkb:Masatoshi_Takeichi
|
|
gptkbp:discoveredIn
|
1977
|
|
gptkbp:downregulationAssociatedWith
|
cancer metastasis
|
|
gptkbp:encodedBy
|
gptkb:CDH1_gene
|
|
gptkbp:expressedIn
|
gptkb:skin
gptkb:prostate
liver
colon
mammary gland
epithelial tissues
|
|
gptkbp:extracellularDomains
|
5
|
|
gptkbp:familyMember
|
gptkb:cadherin_family
|
|
gptkbp:form
|
homodimers
adherens junctions
|
|
gptkbp:foundIn
|
humans
other animals
|
|
gptkbp:function
|
cell adhesion
maintenance of epithelial cell layers
|
|
gptkbp:glycosylation
|
true
|
|
gptkbp:GO
|
GO:0005887 (integral component of plasma membrane)
GO:0005912 (adherens junction)
GO:0007155 (cell adhesion)
|
|
gptkbp:HGNC_ID
|
1748
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
E-cadherin
|
|
gptkbp:interactsWith
|
gptkb:alpha-catenin
gptkb:p120-catenin
gptkb:beta-catenin
|
|
gptkbp:involvedIn
|
epithelial-mesenchymal transition
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_16q22.1
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:lossLeadsTo
|
invasion and metastasis
increased cell motility
loss of cell polarity
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hereditary_diffuse_gastric_cancer
gptkb:lobular_breast_cancer
|
|
gptkbp:OMIM
|
192090
|
|
gptkbp:PDB
|
3Q2V
|
|
gptkbp:requires
|
embryonic development
tissue morphogenesis
|
|
gptkbp:role
|
tumor suppression
|
|
gptkbp:structure
|
transmembrane protein
|
|
gptkbp:target
|
transcriptional repressors (e.g., Snail, Slug, ZEB1)
|
|
gptkbp:UniProtID
|
P12830
|
|
gptkbp:bfsParent
|
gptkb:CTNNB1
|
|
gptkbp:bfsLayer
|
5
|