|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:TP2
EST2
hTRT
|
|
gptkbp:associatedWith
|
gptkb:cancer
aging
|
|
gptkbp:compatibleWith
|
most somatic cells
|
|
gptkbp:component
|
gptkb:telomerase_complex
|
|
gptkbp:discoveredBy
|
gptkb:Carol_Greider
gptkb:Elizabeth_Blackburn
gptkb:Jack_Szostak
|
|
gptkbp:encodes
|
telomerase reverse transcriptase protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000164362
7015
|
|
gptkbp:expressedIn
|
gptkb:germ_cells
stem cells
cancer cells
|
|
gptkbp:fullName
|
telomerase reverse transcriptase
|
|
gptkbp:function
|
maintains telomere ends
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
11730
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TERT
|
|
gptkbp:inhibitedBy
|
TERT inhibitors
|
|
gptkbp:length
|
1132 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:5p15.33
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:glioblastoma
melanoma
bladder cancer
|
|
gptkbp:OMIM
|
187270
|
|
gptkbp:orthologInMouse
|
Tert
|
|
gptkbp:regulates
|
gptkb:HIF-1α
gptkb:c-Jun
gptkb:SP1
gptkb:c-Myb
gptkb:E2F2
gptkb:E2F3
gptkb:E2F4
gptkb:E2F5
gptkb:E2F6
gptkb:E2F7
gptkb:E2F8
gptkb:p21
gptkb:ZEB1
gptkb:c-Myc
gptkb:Menin
gptkb:WT1
gptkb:β-catenin
gptkb:BRCA1
gptkb:E2F1
gptkb:p53
gptkb:MYC
gptkb:STAT3
gptkb:E2F
gptkb:FOXO3a
gptkb:NF-κB
gptkb:c-Fos
gptkb:ETS2
gptkb:TGF-β
gptkb:AP-2
telomere length
estrogen receptor
Oct-4
p50
Oct-3
p65
p52
Smad3
IKKα
IKKβ
IKKγ
RelB
c-Rel
GABP
Oct-1
Oct-11
Oct-12
Oct-13
Oct-14
Oct-15
Oct-16
Oct-17
Oct-18
Oct-19
Oct-2
Oct-20
Oct-21
Oct-22
Oct-23
Oct-24
Oct-25
Oct-26
Oct-27
Oct-28
Oct-29
Oct-30
Oct-6
Oct-7
Oct-9
RelA
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:UniProtID
|
O14746
|
|
gptkbp:bfsParent
|
gptkb:telomerase_complex
gptkb:Telomerase
|
|
gptkbp:bfsLayer
|
7
|