|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CTNNB1
gptkb:catenin_beta-1
|
|
gptkbp:degradedBy
|
gptkb:proteasome
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:encodedBy
|
gptkb:CTNNB1_gene
|
|
gptkbp:formsComplexWith
|
gptkb:TCF/LEF_transcription_factors
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:Wnt_signaling_pathway
cell adhesion
|
|
gptkbp:inhibitedBy
|
gptkb:GSK-3β
|
|
gptkbp:interactsWith
|
gptkb:APC_protein
gptkb:Axin
gptkb:cadherins
|
|
gptkbp:locale
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
3p22.1
|
|
gptkbp:molecularWeight
|
~85 kDa
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
gene transcription
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:role
|
gptkb:medulloblastoma
colorectal cancer
hepatocellular carcinoma
epithelial-mesenchymal transition
stem cell renewal
|
|
gptkbp:structure
|
contains armadillo repeats
|
|
gptkbp:UniProtID
|
gptkb:P35222
|
|
gptkbp:bfsParent
|
gptkb:WNT
gptkb:GSK3
gptkb:Wnt_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
β-catenin
|