|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:AP-1
gptkb:Proto-oncogene_c-Jun
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:binds
|
gptkb:gene
gptkb:TRE_(TPA_response_element)
|
|
gptkbp:discoveredBy
|
gptkb:Raju_Kucherlapati
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:domain
|
basic leucine zipper (bZIP) domain
|
|
gptkbp:downregulatedIn
|
gptkb:miR-124
gptkb:miR-155
|
|
gptkbp:encodedBy
|
gptkb:JUN_gene
|
|
gptkbp:Entrez_Gene_ID
|
3725
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:formsHeterodimerWith
|
gptkb:JunD
gptkb:c-Fos
gptkb:JunB
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:HGNC_ID
|
6204
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-Jun
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p32-p31
|
|
gptkbp:memberOf
|
AP-1 transcription factor complex
|
|
gptkbp:molecularWeight
|
~39 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1JNM
|
|
gptkbp:phosphorylates
|
gptkb:JNK
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:cyclin_D1
gptkb:IL-2
gptkb:FasL
gptkb:MMP-9
gptkb:matrix_metalloproteinases
gene expression
cell cycle
apoptosis-related genes
cytokine genes
|
|
gptkbp:role
|
immune response
oncogenesis
stress response
|
|
gptkbp:UniProtID
|
gptkb:P05412
|
|
gptkbp:upregulatedBy
|
cytokines
growth factors
stress signals
|
|
gptkbp:bfsParent
|
gptkb:JNK_pathway
|
|
gptkbp:bfsLayer
|
6
|