Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
transcription factor |
| gptkbp:activatedBy |
gptkb:virus
stress pro-inflammatory cytokines free radicals bacterial lipopolysaccharides |
| gptkbp:binds |
κB DNA motifs
|
| gptkbp:database |
GeneCards: NFKB
UniProt: Q04206 |
| gptkbp:discoveredBy |
gptkb:David_Baltimore
Ranjan Sen |
| gptkbp:discoveredIn |
1986
|
| gptkbp:encodedBy |
NFKB1 gene
NFKB2 gene REL gene RELA gene RELB gene |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:gene |
NFKB
|
| https://www.w3.org/2000/01/rdf-schema#label |
NF-κB
|
| gptkbp:inhibitedBy |
gptkb:salicylates
gptkb:aspirin gptkb:glucocorticoids IκB proteins |
| gptkbp:location |
cytoplasm (inactive)
nucleus (active) |
| gptkbp:pathway |
canonical pathway
non-canonical pathway |
| gptkbp:regulates |
apoptosis
cell proliferation cell survival inflammation immune response cytokine production DNA transcription |
| gptkbp:regulationMechanism |
phosphorylation
ubiquitination proteasomal degradation IκB degradation |
| gptkbp:relatedTo |
gptkb:cancer
neurodegenerative diseases autoimmune diseases inflammatory diseases |
| gptkbp:subunit |
p50
p52 RelA (p65) RelB c-Rel p100 p105 |
| gptkbp:bfsParent |
gptkb:PI3K-AKT_signaling_pathway
|
| gptkbp:bfsLayer |
6
|