|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:E2F-4
gptkb:E2F_transcription_factor_4,_p107/p130-binding
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
researchers in the 1990s
|
|
gptkbp:domain
|
DNA-binding domain
dimerization domain
transactivation domain
marked box domain
|
|
gptkbp:encodedBy
|
gptkb:E2F4_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000112246
1874
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:E2F_transcription_factor_4
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3115
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
E2F4
|
|
gptkbp:interactsWith
|
gptkb:RB_protein_family
gptkb:DP1
p107
p130
|
|
gptkbp:involvedIn
|
tumorigenesis
|
|
gptkbp:length
|
413 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:16q22
|
|
gptkbp:memberOf
|
gptkb:E2F_family
|
|
gptkbp:molecularWeight
|
45 kDa
|
|
gptkbp:motif
|
E2F DNA-binding motif
|
|
gptkbp:OMIM
|
600426
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:phosphorylates
|
regulates activity
|
|
gptkbp:regulates
|
gptkb:G1/S_transition
gene expression
DNA replication
cell cycle
|
|
gptkbp:relatedTo
|
gptkb:cancer
cell differentiation
cell proliferation
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:OMIM
gptkb:UniProt
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q16254
|
|
gptkbp:bfsParent
|
gptkb:E2F_transcription_factors
gptkb:E2F
|
|
gptkbp:bfsLayer
|
7
|