|
gptkbp:instanceOf
|
gptkb:gene
tumor suppressor
|
|
gptkbp:alias
|
gptkb:c-Myc
gptkb:MYCC
gptkb:bHLHe39
|
|
gptkbp:associatedWith
|
gptkb:Burkitt_lymphoma
multiple cancers
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:encodes
|
gptkb:c-Myc_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:MYC
4609
ENSG00000136997
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:HGNC_ID
|
7553
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MYC
|
|
gptkbp:interactsWith
|
gptkb:MAX
gptkb:SP1
gptkb:MIZ-1
gptkb:TFAP4
|
|
gptkbp:length
|
439 amino acids
4395 bp
|
|
gptkbp:locatedOnChromosome
|
gptkb:8q24
|
|
gptkbp:mutationAssociatedWith
|
translocation
amplification
overexpression
|
|
gptkbp:OMIM
|
190080
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInFruitFly
|
dm
|
|
gptkbp:orthologInMouse
|
gptkb:Myc
|
|
gptkbp:orthologInZebrafish
|
myca
|
|
gptkbp:proteinFamily
|
basic helix-loop-helix leucine zipper
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell growth
cell cycle
regulated by Notch signaling
regulated by TGF-beta signaling
regulated by Wnt signaling
upregulated in many tumors
|
|
gptkbp:target
|
gptkb:RNA_interference
therapeutic research
antisense oligonucleotides
small molecule inhibitors
|
|
gptkbp:transcriptionEndSite
|
chr8:128753680 (GRCh38)
|
|
gptkbp:transcriptionStartSite
|
chr8:128748315 (GRCh38)
|
|
gptkbp:UniProtID
|
P01106
|
|
gptkbp:bfsParent
|
gptkb:basic_helix-loop-helix_(bHLH)_family
gptkb:EGR1
gptkb:8q24.22
gptkb:c-Myc
|
|
gptkbp:bfsLayer
|
6
|