|
gptkbp:instanceOf
|
gptkb:ribonucleoprotein
gptkb:enzyme
|
|
gptkbp:activeIn
|
gptkb:germ_cells
stem cells
cancer cells
|
|
gptkbp:alternativeName
|
gptkb:telomere_synthase
gptkb:telomere_terminal_transferase
|
|
gptkbp:associatedWith
|
gptkb:dyskeratosis_congenita
aplastic anemia
idiopathic pulmonary fibrosis
|
|
gptkbp:biologicalProcess
|
RNA binding
DNA binding
nucleotidyltransferase activity
|
|
gptkbp:catalyzes
|
gptkb:reverse_transcriptase
|
|
gptkbp:discoveredBy
|
gptkb:Carol_Greider
gptkb:Elizabeth_Blackburn
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:EC_number
|
2.7.7.49
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
extends telomeres
adds DNA sequence repeats to telomere ends
|
|
gptkbp:gene
|
gptkb:TERC
gptkb:TERT
|
|
gptkbp:GO_term
|
gptkb:GO:0003691
|
|
gptkbp:hasComponent
|
gptkb:TERC
gptkb:TERT
|
|
gptkbp:inactiveIn
|
most somatic cells
|
|
gptkbp:inhibitedBy
|
gptkb:BIBR1532
gptkb:Imetelstat
|
|
gptkbp:locatedIn
|
gptkb:nucleus
|
|
gptkbp:OMIM
|
187270
|
|
gptkbp:PDB
|
6D6V
|
|
gptkbp:regulates
|
downregulated in somatic cells
upregulated in cancer
|
|
gptkbp:relatedTo
|
gptkb:reverse_transcriptase
telomere
|
|
gptkbp:RNA_template
|
gptkb:TERC
|
|
gptkbp:role
|
gptkb:cancer
cellular aging
chromosome stability
|
|
gptkbp:structure
|
protein and RNA components
|
|
gptkbp:subunit
|
catalytic subunit
RNA subunit
|
|
gptkbp:symbol
|
gptkb:TERC_(human)
gptkb:hTERT_(human)
|
|
gptkbp:target
|
gptkb:cancer
anti-aging research
|
|
gptkbp:UniProtID
|
O14746
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Telomerase
|