Statements (113)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Biology
|
| gptkbp:activities |
varies among different cell types
is regulated by various factors |
| gptkbp:affiliated_with |
cancer cells
|
| gptkbp:associated_with |
cellular aging
|
| gptkbp:benefits |
of targeting in therapy
|
| gptkbp:case_types |
associated with various cancers
|
| gptkbp:clinical_trial |
in oncology
testing inhibitors |
| gptkbp:clinical_use |
of telomerase inhibitors
|
| gptkbp:collaborations |
are common in the field
|
| gptkbp:complex |
with telomerase RNA
|
| gptkbp:components |
the telomerase complex
|
| gptkbp:composed_of |
RNA and protein components
|
| gptkbp:conducts_research_on |
regenerative therapies
|
| gptkbp:discovered_by |
gptkb:Carol_Greider
gptkb:Elizabeth_Blackburn gptkb:Jack_Szostak |
| gptkbp:discovery |
linked to cellular aging
|
| gptkbp:ecological_role |
in cellular immortality
|
| gptkbp:educational_resources |
are available for understanding its function.
|
| gptkbp:expression_patterns |
can vary with tumor type
|
| gptkbp:function |
extends the lifespan of cells
adds nucleotide sequences to the ends of chromosomes |
| gptkbp:funding |
is increasing
|
| gptkbp:future_plans |
in cancer research
|
| gptkbp:has_a_focus_on |
cancer research
aging research molecular biology studies molecular genetics research cancer therapy development |
| gptkbp:has_implications_for |
for aging and cancer biology
|
| https://www.w3.org/2000/01/rdf-schema#label |
Telomerase
|
| gptkbp:inhibition |
potential cancer therapy
|
| gptkbp:inhibitor_development |
is a growing field
|
| gptkbp:inhibitor_types |
gptkb:immunotherapy
small molecules RNA-based therapies |
| gptkbp:initiated_by |
under investigation
can be used in cancer therapy telomerase RNA component (TERC) mutations telomerase reverse transcriptase (TERT) |
| gptkbp:is_a_subject_of |
clinical trials
biomedical research genetic engineering studies |
| gptkbp:is_absent_in |
most somatic cells
|
| gptkbp:is_associated_with |
telomere biology
telomere maintenance mechanisms increased lifespan in some organisms telomere lengthening |
| gptkbp:is_essential_for |
germline development
immortalization of cells |
| gptkbp:is_expressed_in |
embryonic stem cells
high in stem cells low in somatic cells high in germ cells certain adult tissues certain types of tumors |
| gptkbp:is_found_in |
gptkb:Cell
cancer cells germ cells |
| gptkbp:is_involved_in |
DNA replication
DNA damage response chromosomal stability tumorigenesis cellular differentiation genomic stability stem cell maintenance chromosome end protection |
| gptkbp:is_linked_to |
cell cycle regulation
genetic disorders cellular proliferation various diseases cancer progression telomere shortening proliferative capacity of cells |
| gptkbp:is_studied_for_its_potential_in |
anti-cancer therapies
|
| gptkbp:is_studied_in |
regenerative medicine
aging processes |
| gptkbp:is_tested_for |
for cancer prognosis
|
| gptkbp:key_player |
cellular immortality
|
| gptkbp:measures |
telomerase activity assays
|
| gptkbp:mechanism_of_action |
adds repetitive nucleotide sequences to telomeres
|
| gptkbp:overexpression |
promotes tumorigenesis
|
| gptkbp:pathway |
involved in telomere maintenance
|
| gptkbp:promoter |
gptkb:TERT
|
| gptkbp:public_awareness |
of its role in cancer is growing
|
| gptkbp:publications |
on its role in cancer are numerous
|
| gptkbp:regulatory_compliance |
is complex
|
| gptkbp:research |
is key to understanding its function
ongoing in cancer treatment |
| gptkbp:research_areas |
include gene therapy
|
| gptkbp:research_focus |
telomerase-targeted therapies
|
| gptkbp:research_interest |
is high due to its role in cancer
|
| gptkbp:role |
maintains telomere length
|
| gptkbp:side_effect |
of telomerase inhibition
|
| gptkbp:target_validation |
is necessary for drug development
|
| gptkbp:targets |
gptkb:gene_therapy
anticancer drugs pharmaceutical interventions anti-aging research |
| gptkbp:telomerase_reverse_transcriptase |
is a component
|
| gptkbp:telomere |
protects chromosome ends
|
| gptkbp:telomere_dysfunction |
can lead to genomic instability
|
| gptkbp:telomere_length |
is associated with aging
|
| gptkbp:telomere_lengthening |
is a mechanism of cancer progression
|
| gptkbp:telomere_maintenance |
is crucial for cancer cell survival
|
| gptkbp:telomere_shortening |
leads to cell senescence
|
| gptkbp:therapeutic_challenges |
in targeting cancer cells
|
| gptkbp:therapeutic_strategies |
targeting telomerase
|
| gptkbp:therapeutic_window |
is a consideration in treatment
|
| gptkbp:was_a_factor_in |
cellular homeostasis
cellular senescence |