|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
AREB6
TCF8
ZFHX1A
|
|
gptkbp:associatedWith
|
gptkb:corneal_dystrophy
cancer progression
Fuchs endothelial corneal dystrophy
|
|
gptkbp:binds
|
E-box DNA sequences
|
|
gptkbp:encodes
|
ZEB1 protein
|
|
gptkbp:Entrez_Gene_ID
|
6935
ENSG00000148516
|
|
gptkbp:expressedIn
|
various tissues
tumor cells
embryonic tissues
|
|
gptkbp:fullName
|
zinc finger E-box-binding homeobox 1
|
|
gptkbp:function
|
transcription factor
regulation of epithelial-mesenchymal transition
|
|
gptkbp:HGNC_ID
|
HGNC:11642
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ZEB1
|
|
gptkbp:inhibitedBy
|
gptkb:CDH1_gene
|
|
gptkbp:interactsWith
|
gptkb:BRG1
gptkb:SMAD_proteins
gptkb:p300
CtBP1
CtBP2
|
|
gptkbp:locatedOnChromosome
|
10
10p11.22
|
|
gptkbp:mutationAssociatedWith
|
gptkb:posterior_polymorphous_corneal_dystrophy
gptkb:Mowat-Wilson_syndrome
|
|
gptkbp:orthologInMouse
|
Zeb1
|
|
gptkbp:orthologInZebrafish
|
zeb1a
zeb1b
|
|
gptkbp:proteinFamily
|
zinc finger homeodomain proteins
|
|
gptkbp:regulates
|
gptkb:TGF-beta_signaling_pathway
gptkb:Notch_signaling_pathway
gptkb:Wnt_signaling_pathway
gptkb:E-cadherin
apoptosis
cell differentiation
cell proliferation
cell migration
immune response
stem cell properties
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:transcriptionalActivatorOf
|
mesenchymal genes
|
|
gptkbp:transcriptionalRepressorOf
|
epithelial genes
|
|
gptkbp:UniProtID
|
P37275
|
|
gptkbp:bfsParent
|
gptkb:chromosome_10
|
|
gptkbp:bfsLayer
|
6
|