|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:anemia
ischemia
|
|
gptkbp:degradedBy
|
gptkb:proteasome
gptkb:VHL_protein
oxygen levels
|
|
gptkbp:discoveredBy
|
gptkb:Gregg_L._Semenza
|
|
gptkbp:domain
|
transactivation domain
PAS domain
bHLH domain
|
|
gptkbp:encodedBy
|
gptkb:HIF1A_gene
|
|
gptkbp:formsComplexWith
|
gptkb:HIF-1β
|
|
gptkbp:fullName
|
gptkb:Hypoxia-inducible_factor_1-alpha
|
|
gptkbp:function
|
transcription factor
DNA binding
transcriptional activator activity
regulates response to hypoxia
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HIF-1α
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
14q23.2
|
|
gptkbp:molecularWeight
|
~93 kDa
|
|
gptkbp:PDB
|
1H2M
|
|
gptkbp:postTranslationalModification
|
ubiquitination
hydroxylation
|
|
gptkbp:regulates
|
gptkb:LDHA
gptkb:EPO
gptkb:GLUT1
gptkb:VEGF
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
Q16665
|
|
gptkbp:bfsParent
|
gptkb:VEGF_signaling_pathway
gptkb:hypoxia-inducible_factor_1_(HIF-1)
gptkb:mechanistic_target_of_rapamycin_pathway
gptkb:mTORC1
|
|
gptkbp:bfsLayer
|
6
|