Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cytokine |
| gptkbp:abbreviation |
gptkb:TGF-beta
|
| gptkbp:associatedWith |
gptkb:cancer
gptkb:Marfan_syndrome gptkb:systemic_sclerosis autoimmune diseases pulmonary fibrosis liver cirrhosis |
| gptkbp:discoveredBy |
gptkb:Anita_B._Roberts
gptkb:Michael_B._Sporn |
| gptkbp:discoveredIn |
1983
|
| gptkbp:encodedBy |
TGFB1 gene
|
| gptkbp:enemyOf |
gptkb:follistatin
gptkb:alpha2-macroglobulin gptkb:decorin |
| gptkbp:fullName |
Transforming Growth Factor Beta
|
| gptkbp:function |
regulation of apoptosis
regulation of cell differentiation regulation of cell growth regulation of immune response |
| gptkbp:hasIsoform |
TGF-β1
TGF-β3 TGF-β2 |
| https://www.w3.org/2000/01/rdf-schema#label |
TGF-β
|
| gptkbp:involvedIn |
embryonic development
wound healing cancer progression fibrosis immune suppression |
| gptkbp:location |
secreted protein
extracellular space |
| gptkbp:medicalUse |
target for cancer therapy
target for anti-fibrotic drugs |
| gptkbp:memberOf |
gptkb:TGF-beta_superfamily
|
| gptkbp:OMIM |
190180 (TGF-β1)
|
| gptkbp:orthologIn |
gptkb:activin
inhibin bone morphogenetic protein |
| gptkbp:pathway |
gptkb:SMAD_pathway
non-SMAD pathway |
| gptkbp:recipient |
TGF-β receptor
|
| gptkbp:regulates |
cell proliferation
angiogenesis inflammation epithelial-mesenchymal transition extracellular matrix production |
| gptkbp:structure |
dimeric protein
|
| gptkbp:UniProtID |
P01137 (TGF-β1)
|
| gptkbp:bfsParent |
gptkb:IFN-γ
gptkb:TGF-beta |
| gptkbp:bfsLayer |
7
|