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gptkbp:instanceOf
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gptkb:gene
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gptkbp:alternativeName
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gptkb:MEK1
gptkb:MAPKK1
gptkb:PRKMK1
|
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gptkbp:associatedWith
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gptkb:Cardiofaciocutaneous_syndrome
gptkb:Noonan_syndrome
Various cancers
|
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gptkbp:discoveredBy
|
independent research groups in the 1990s
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gptkbp:encodes
|
gptkb:Mitogen-activated_protein_kinase_kinase_1
|
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gptkbp:Entrez_Gene_ID
|
5604
ENSG00000169032
|
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gptkbp:expressedIn
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various tissues
|
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gptkbp:function
|
phosphorylates and activates MAPK1/ERK2 and MAPK3/ERK1
|
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gptkbp:geneType
|
protein coding
|
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gptkbp:hasTranscriptVariant
|
multiple
|
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gptkbp:HGNC_ID
|
6840
|
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gptkbp:inhibitedBy
|
gptkb:Binimetinib
gptkb:Cobimetinib
gptkb:Trametinib
|
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gptkbp:locatedOnChromosome
|
gptkb:chromosome_15
15q22.31
|
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gptkbp:mutationAssociatedWith
|
developmental disorders
oncogenesis
|
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gptkbp:OMIM
|
176872
|
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gptkbp:orthologInMouse
|
gptkb:Map2k1
|
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gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
|
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gptkbp:phosphorylates
|
gptkb:ERK1
gptkb:ERK2
|
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gptkbp:product
|
gptkb:MEK1_protein
|
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gptkbp:proteinFamily
|
dual specificity protein kinases
|
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gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
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gptkbp:UniProtID
|
Q02750
|
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gptkbp:bfsParent
|
gptkb:Cardiofaciocutaneous_syndrome
gptkb:RTK-RAS_pathway
|
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gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP2K1 gene
|