|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:MEK1
gptkb:MAPKK1
gptkb:PRKMK1
|
|
gptkbp:associatedWith
|
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Noonan_syndrome
Various cancers
|
|
gptkbp:discoveredBy
|
independent research groups in the 1990s
|
|
gptkbp:encodes
|
gptkb:Mitogen-activated_protein_kinase_kinase_1
|
|
gptkbp:Entrez_Gene_ID
|
5604
ENSG00000169032
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
phosphorylates and activates MAPK1/ERK2 and MAPK3/ERK1
|
|
gptkbp:geneType
|
protein coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
6840
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP2K1 gene
|
|
gptkbp:inhibitedBy
|
gptkb:Binimetinib
gptkb:Cobimetinib
gptkb:Trametinib
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15
15q22.31
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
oncogenesis
|
|
gptkbp:OMIM
|
176872
|
|
gptkbp:orthologInMouse
|
gptkb:Map2k1
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:phosphorylates
|
gptkb:ERK1
gptkb:ERK2
|
|
gptkbp:product
|
gptkb:MEK1_protein
|
|
gptkbp:proteinFamily
|
dual specificity protein kinases
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:UniProtID
|
Q02750
|
|
gptkbp:bfsParent
|
gptkb:cardiofaciocutaneous_syndrome
gptkb:Cardiofaciocutaneous_syndrome
gptkb:RTK-RAS_pathway
|
|
gptkbp:bfsLayer
|
6
|