|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:B-RAF1
gptkb:BRAF-1
gptkb:BRAF1
gptkb:NS7
gptkb:RAFB1
|
|
gptkbp:chromosomeArm
|
gptkb:7q34
|
|
gptkbp:discoveredBy
|
Marais et al.
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:B-Raf_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000157764
gptkb:BRAF
673
|
|
gptkbp:fullName
|
gptkb:B-Raf_proto-oncogene,_serine/threonine_kinase
|
|
gptkbp:function
|
gptkb:MAPK/ERK_signaling_pathway
protein kinase activity
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:1097
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BRAF gene
|
|
gptkbp:KEGGID
|
hsa:673
|
|
gptkbp:locatedOnChromosome
|
7
|
|
gptkbp:location
|
gptkb:7q34
|
|
gptkbp:mutationAssociatedWith
|
gptkb:V600K
gptkb:cardiofaciocutaneous_syndrome
gptkb:cancer
gptkb:Noonan_syndrome
gptkb:Langerhans_cell_histiocytosis
colorectal cancer
leukemia
melanoma
D594G
G469A
V600E
|
|
gptkbp:OMIM
|
164757
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Braf
|
|
gptkbp:orthologInZebrafish
|
braf
|
|
gptkbp:pathway
|
gptkb:RAS_signaling_pathway
gptkb:MAPK_signaling_pathway
ERK1/2 cascade
|
|
gptkbp:product
|
gptkb:B-Raf_protein
|
|
gptkbp:proteinFamily
|
gptkb:RAF_kinase_family
|
|
gptkbp:Reactome
|
gptkb:R-HSA-5673001
|
|
gptkbp:target
|
gptkb:encorafenib
gptkb:dabrafenib
gptkb:sorafenib
gptkb:vemurafenib
|
|
gptkbp:UniProtID
|
gptkb:P15056
|
|
gptkbp:bfsParent
|
gptkb:cancer
|
|
gptkbp:bfsLayer
|
4
|