Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:KRAS_G12_V
gptkb:KRAS_G13_D |
| gptkbp:associated_with |
gptkb:healthcare_organization
|
| gptkbp:code |
Kirsten rat sarcoma viral oncogene homolog protein
|
| gptkbp:discovered_by |
M. R. Mc Cormick
|
| gptkbp:genetic_diversity |
gptkb:healthcare_organization
point mutation |
| gptkbp:has_role |
apoptosis
cell differentiation cell proliferation |
| gptkbp:has_variants |
gptkb:KRAS_G12_D
gptkb:KRAS_G12_V gptkb:KRAS_G13_D gptkb:KRAS_Q61_H |
| https://www.w3.org/2000/01/rdf-schema#label |
KRAS gene
|
| gptkbp:is_aimed_at |
KRAS inhibitors
cancer therapies |
| gptkbp:is_associated_with |
disease progression
tumor heterogeneity metastasis poor prognosis therapeutic resistance |
| gptkbp:is_essential_for |
normal cell function
|
| gptkbp:is_involved_in |
MAPK signaling pathway
cell cycle regulation cellular stress response immune response signal transduction inflammation cell signaling pathways tumorigenesis cell survival tumor microenvironment angiogenesis cell adhesion cell migration stem cell maintenance tumor progression tumor angiogenesis immune evasion metabolic reprogramming cell invasion P I3 K-AKT signaling pathway |
| gptkbp:is_linked_to |
genomic instability
epigenetic changes chronic inflammation drug resistance favorable response to treatment unfavorable response to treatment |
| gptkbp:is_part_of |
gptkb:physicist
cytoplasm cell membrane Ras protein family Ras-MAPK pathway Ras-P I3 K pathway |
| gptkbp:is_recognized_by |
rat
|
| gptkbp:is_represented_in |
various tissues
|
| gptkbp:is_studied_in |
clinical trials
oncology therapeutic interventions targeted therapies precision medicine biomarker development |
| gptkbp:located_in |
human chromosome 12
|
| gptkbp:regulates |
growth factors
hormones |