|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:Ki-ras
gptkb:RASK2
gptkb:c-K-ras
|
|
gptkbp:associatedWith
|
gptkb:HRAS
gptkb:NRAS
gptkb:cancer
gptkb:endometrial_cancer
colorectal cancer
pancreatic cancer
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodes
|
gptkb:KRAS_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000133703
3845
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:function
|
signal transduction
GTPase activity
|
|
gptkbp:geneType
|
tumor suppressor
|
|
gptkbp:hasIsoform
|
gptkb:KRAS4A
gptkb:KRAS4B
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
6407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KRAS gene
|
|
gptkbp:length
|
189 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12p12.1
|
|
gptkbp:memberOf
|
gptkb:RAS_gene_family
|
|
gptkbp:mutationAssociatedWith
|
drug resistance
missense mutation
point mutation
uncontrolled cell proliferation
codon 12
codon 13
codon 61
oncogenic transformation
|
|
gptkbp:OMIM
|
190070
|
|
gptkbp:orthologInMouse
|
gptkb:Kras
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:targetOfDrug
|
gptkb:adagrasib
gptkb:sotorasib
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:MAPK/ERK_pathway
gptkb:KRAS_mutation
|
|
gptkbp:bfsLayer
|
5
|