|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:MEK2_gene
gptkb:Mitogen-activated_protein_kinase_kinase_2
|
|
gptkbp:associatedWith
|
gptkb:cardiofaciocutaneous_syndrome
gptkb:cancer
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:MEK2_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000126934
5605
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
phosphorylates and activates MAPK1/ERK2 and MAPK3/ERK1
|
|
gptkbp:geneType
|
protein coding
|
|
gptkbp:HGNC_ID
|
6840
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP2K2 gene
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.3
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
|
|
gptkbp:OMIM
|
601263
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Map2k2
|
|
gptkbp:RefSeq
|
gptkb:NM_030662
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:target
|
pharmacological inhibitors (e.g., MEK inhibitors)
|
|
gptkbp:UniProtID
|
P36507
|
|
gptkbp:bfsParent
|
gptkb:MEK2
gptkb:cardiofaciocutaneous_syndrome
gptkb:Cardiofaciocutaneous_syndrome
gptkb:RTK-RAS_pathway
|
|
gptkbp:bfsLayer
|
6
|