|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:ERK-1
gptkb:Extracellular_signal-regulated_kinase_1
gptkb:PRKM3
gptkb:p44-ERK1
|
|
gptkbp:alternativeName
|
gptkb:ERK1
gptkb:p44MAPK
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodevelopmental disorders
|
|
gptkbp:encodes
|
gptkb:Mitogen-activated_protein_kinase_3
|
|
gptkbp:Entrez_Gene_ID
|
5595
ENSG00000102882
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
regulation of cell proliferation
regulation of transcription
regulation of differentiation
regulation of development
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPK3 gene
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
signal transduction
cellular response to extracellular stimuli
response to cytokines
response to growth factors
response to stress
|
|
gptkbp:length
|
379 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:16p11.2
gptkb:chromosome_16
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autism_spectrum_disorder
gptkb:16p11.2_deletion_syndrome
schizophrenia
|
|
gptkbp:OMIM
|
601795
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Mapk3
|
|
gptkbp:phosphorylates
|
gptkb:MAP2K1
gptkb:MAP2K2
|
|
gptkbp:product
|
gptkb:MAPK3_protein
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell survival
cell migration
transcription factors
cell cycle proteins
|
|
gptkbp:relatedTo
|
gptkb:MAP2K1_gene
gptkb:MAP2K2_gene
gptkb:MAPK1_gene
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P27361
|
|
gptkbp:bfsParent
|
gptkb:ERK
gptkb:RTK-RAS_pathway
|
|
gptkbp:bfsLayer
|
6
|