SOS1 gene

URI: https://gptkb.org/entity/SOS1_gene
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alternativeName gptkb:Son_of_sevenless_1
gptkb:SOS-1
gptkbp:associatedWith gptkb:SOS2_gene
gptkb:hereditary_gingival_fibromatosis
gptkb:Noonan_syndrome
gptkbp:biologicalProcess activates RAS by facilitating GDP-GTP exchange
gptkbp:discoveredIn 1993
gptkbp:encodes gptkb:SOS1_protein
gptkbp:Entrez_Gene_ID 6654
gptkbp:expressedIn various tissues
gptkbp:fullName gptkb:Son_of_sevenless_homolog_1
gptkbp:function gptkb:guanine_nucleotide_exchange_factor
gptkbp:geneType protein-coding
gptkbp:HGNC_ID 11187
gptkbp:interactsWith gptkb:EGFR
gptkb:SHC1
gptkb:GRB2
gptkbp:involvedIn gptkb:RAS/MAPK_signaling_pathway
gptkbp:length 23 exons
gptkbp:locatedOnChromosome 2p22-p16
plus
gptkbp:mutationAssociatedWith gain-of-function mutations cause Noonan syndrome
mutations can cause developmental disorders
gptkbp:OMIM 182530
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkbp:product gptkb:SOS1_protein
gptkbp:regulates RAS activation
gptkbp:UniProtID Q07889
gptkbp:bfsParent gptkb:RTK-RAS_pathway
gptkbp:bfsLayer 6
https://www.w3.org/2000/01/rdf-schema#label SOS1 gene