|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:c-Ha-ras
gptkb:HRAS1
gptkb:transforming_protein_p21
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Costello_syndrome
gptkb:head_and_neck_squamous_cell_carcinoma
bladder cancer
|
|
gptkbp:clinicalTrialPhase
|
HRAS mutation analysis
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodes
|
gptkb:HRas_protein
|
|
gptkbp:Entrez_Gene_ID
|
3265
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:function
|
signal transduction
GTPase activity
|
|
gptkbp:gene
|
gptkb:HRAS
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
5173
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HRAS gene
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
apoptosis regulation
|
|
gptkbp:length
|
189 amino acids
6 exons
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
chromosome 11
|
|
gptkbp:mRNA_length
|
~1.3 kb
|
|
gptkbp:mutationAssociatedWith
|
codon 12
codon 13
codon 61
oncogenic mutation
constitutive activation of Ras pathway
|
|
gptkbp:OMIM
|
190020
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Hras1
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:proteinFamily
|
gptkb:Ras_family
gptkb:GTP-binding_domain
|
|
gptkbp:regulates
|
regulated by GTP/GDP binding
|
|
gptkbp:subcellularLocation
|
gptkb:Golgi_apparatus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:Ras_proteins
gptkb:Costello_syndrome
gptkb:GTPase_HRas
gptkb:RAS_protein
gptkb:RTK-RAS_pathway
gptkb:Ras-GTP
gptkb:Transforming_protein_p21
gptkb:transforming_protein_p21
|
|
gptkbp:bfsLayer
|
6
|