RTK-RAS-RAF-MEK-ERK pathway

URI: https://gptkb.org/entity/RTK-RAS-RAF-MEK-ERK_pathway
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf signaling molecule
gptkbp:activatedBy cytokines
growth factors
hormones
gptkbp:alsoKnownAs gptkb:MAPK/ERK_pathway
gptkbp:componentOrder RTK → RAS → RAF → MEK → ERK
gptkbp:dysregulationAssociatedWith gptkb:cancer
developmental disorders
gptkbp:ERKPhosphorylates transcription factors
gptkbp:ERKTranslocatesTo gptkb:nucleus
gptkbp:function cell differentiation
cell proliferation
cell survival
gene expression regulation
https://www.w3.org/2000/01/rdf-schema#label RTK-RAS-RAF-MEK-ERK pathway
gptkbp:involves gptkb:MEK_(MAPK/ERK_kinase)
gptkb:RAF_kinase
gptkb:ERK_(extracellular_signal-regulated_kinase)
gptkb:RAS_protein
receptor tyrosine kinases (RTKs)
gptkbp:MEKPhosphorylates gptkb:ERK
gptkbp:RAFPhosphorylates gptkb:MEK
gptkbp:RASActivates gptkb:RAF
gptkbp:regulates apoptosis
metabolism
cell cycle progression
gptkbp:RTKActivates gptkb:RAS
gptkbp:species gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:target gptkb:MEK_inhibitors
gptkb:RAF_inhibitors
ERK inhibitors
gptkbp:bfsParent gptkb:RTK-RAS_pathway
gptkbp:bfsLayer 6