|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:alternativeName
|
gptkb:EIP38
gptkb:ERK-1
gptkb:MAP_kinase_3
gptkb:Mitogen-activated_protein_kinase_3
gptkb:PRKM3
gptkb:p44-ERK
gptkb:p44-ERK1
gptkb:p44-MAPK
|
|
gptkbp:biologicalProcess
|
protein serine/threonine kinase activity
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodedBy
|
gptkb:MAPK3_gene
|
|
gptkbp:enzymeClassification
|
gptkb:EC_2.7.11.24
|
|
gptkbp:fullName
|
gptkb:Extracellular_signal-regulated_kinase_1
|
|
gptkbp:function
|
signal transduction
regulation of cell cycle
regulation of cell proliferation
regulation of transcription
regulation of differentiation
|
|
gptkbp:gene
|
gptkb:MAPK3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ERK1
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
differentiation
proliferation
apoptosis regulation
cellular response to growth factors
transcription regulation
cellular response to cytokines
cellular response to mitogens
|
|
gptkbp:length
|
379 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:16p11.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:ERK_subfamily
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:phosphorylates
|
gptkb:ELK1
gptkb:RSK
gptkb:c-Myc
gptkb:c-Fos
threonine 202
tyrosine 204
|
|
gptkbp:relatedTo
|
gptkb:ERK2
gptkb:MAPK1
|
|
gptkbp:structure
|
protein kinase domain
|
|
gptkbp:UniProtID
|
gptkb:P27361
|
|
gptkbp:bfsParent
|
gptkb:MEK1
gptkb:MEK2
gptkb:RTK-RAS_pathway
gptkb:extracellular_signal-regulated_kinase
gptkb:mitogen-activated_protein_kinase
|
|
gptkbp:bfsLayer
|
6
|