|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
DNA damage
oncogenic stress
|
|
gptkbp:alsoKnownAs
|
gptkb:p53
|
|
gptkbp:degradedBy
|
gptkb:proteasome
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_Levine
gptkb:David_Lane
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:encodedBy
|
gptkb:TP53_gene
|
|
gptkbp:Entrez_Gene_ID
|
7157
|
|
gptkbp:expressedIn
|
most human tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
tumor suppressor
transcription factor
|
|
gptkbp:hasDNA-bindingDomain
|
yes
|
|
gptkbp:hasOligomerizationDomain
|
yes
|
|
gptkbp:hasRegulatoryDomain
|
yes
|
|
gptkbp:hasTransactivationDomain
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
phosphoprotein p53
|
|
gptkbp:inhibitedBy
|
gptkb:MDM2
viral proteins
|
|
gptkbp:interactsWith
|
gptkb:ATR
gptkb:BAX
gptkb:GADD45
gptkb:p21
gptkb:MDM2
ATM
|
|
gptkbp:length
|
393
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:molecularWeight_kDa
|
43.7
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
high in human cancers
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
apoptosis
DNA repair
angiogenesis
cell cycle
senescence
|
|
gptkbp:role
|
genome stability
response to cellular stress
prevention of tumor formation
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:NP_005017.2
|
|
gptkbp:bfsLayer
|
6
|