P18146

GPTKB entity

Statements (56)
Predicate Object
gptkbp:instanceOf UniProt accession number
gptkbp:alternativeName gptkb:Antigen_NY-CO-13
gptkb:Phosphoprotein_p53
gptkb:Tumor_suppressor_p53
gptkbp:associatedWith gptkb:Li-Fraumeni_syndrome
Various cancers
gptkbp:biologicalProcess DNA-binding
Transcription factor
gptkbp:database gptkb:UniProtKB/Swiss-Prot
gptkbp:discoveredIn 1979
gptkbp:Entrez_Gene_ID 7157
ENSG00000141510
gptkbp:enzymeRegulation Regulated by MDM2
gptkbp:expressedIn Ubiquitous
gptkbp:function Acts as a tumor suppressor in many tumor types
Involved in DNA repair
Involved in apoptosis
Involved in senescence
Regulates cell cycle
gptkbp:gene gptkb:TP53
gptkbp:GO gptkb:GO:0006355_(regulation_of_transcription,_DNA-templated)
GO:0003677 (DNA binding)
GO:0008285 (negative regulation of cell proliferation)
gptkbp:hasIsoform Multiple
gptkbp:HGNC_ID 11998
https://www.w3.org/2000/01/rdf-schema#label P18146
gptkbp:locatedOnChromosome 17p13.1
gptkbp:mass 43903 Da
gptkbp:OMIM 191170
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Mouse_Trp53
gptkb:Zebrafish_tp53
gptkbp:pathway p53 signaling pathway
gptkbp:PDB gptkb:2OCJ
gptkb:3KMD
gptkb:4HJE
1TUP
5XVK
gptkbp:postTranslationalModification Methylation
Phosphorylation
Acetylation
Ubiquitination
Sumoylation
gptkbp:protein_name gptkb:Cellular_tumor_antigen_p53
gptkbp:proteinFamily gptkb:p53_family
gptkbp:refersTo Human protein: Tumor protein p53
gptkbp:RefSeq NP_000537.3
gptkbp:sequence 393
gptkbp:status Reviewed
gptkbp:structure Tetramer
gptkbp:subcellularLocation gptkb:Mitochondrion
gptkb:Nucleus
gptkb:Cytoplasm
gptkbp:UniProt_entry_name gptkb:P53_HUMAN
gptkbp:bfsParent gptkb:EGR1
gptkbp:bfsLayer 6