Statements (65)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:code |
gptkb:TP53_gene
|
| gptkbp:function |
tumor suppressor
|
| gptkbp:genetic_studies |
gptkb:Li-Fraumeni_syndrome
associated with cancer |
| gptkbp:has_role |
senescence
|
| https://www.w3.org/2000/01/rdf-schema#label |
p53α
|
| gptkbp:initiated_by |
gptkb:MDM2
cell proliferation DNA damage DNA repair genes |
| gptkbp:interacts_with |
gptkb:MDM2
|
| gptkbp:involved_in |
apoptosis
cell cycle regulation |
| gptkbp:is_associated_with |
gptkb:Oncology
|
| gptkbp:is_essential_for |
genome stability
|
| gptkbp:is_involved_in |
cellular homeostasis
immune response cellular senescence tumor suppression tumorigenesis tumor microenvironment cellular differentiation cancer progression angiogenesis metastasis cellular signaling pathways cellular signaling metabolism regulation cancer cell growth cellular repair mechanisms cellular growth control cellular apoptosis pathways cellular stress response pathways cellular survival pathways cancer metastasis cancer therapy resistance cancer cell metabolism cancer cell signaling cancer cell angiogenesis cancer cell apoptosis cancer cell differentiation cancer cell dormancy cancer cell heterogeneity cancer cell immune evasion cancer cell invasion cancer cell migration cancer cell plasticity cancer cell proliferation cancer cell reprogramming cancer cell senescence cancer cell survival response to DNA damage response to hypoxia response to oxidative stress |
| gptkbp:is_linked_to |
aging
|
| gptkbp:is_part_of |
p53 pathway
|
| gptkbp:is_regulated_by |
micro RNAs
|
| gptkbp:is_studied_in |
clinical trials
|
| gptkbp:is_targeted_at |
cancer therapies
|
| gptkbp:location |
gptkb:Atom
|
| gptkbp:promoter |
gptkb:TP53
|
| gptkbp:regulates |
cellular stress response
|
| gptkbp:bfsParent |
gptkb:p53
|
| gptkbp:bfsLayer |
6
|