|
gptkbp:instanceOf
|
gptkb:UniProt_accession_number
|
|
gptkbp:alternativeName
|
gptkb:Antigen_NY-CO-13
gptkb:Phosphoprotein_p53
gptkb:Tumor_suppressor_p53
gptkb:Transformation-related_protein_53
|
|
gptkbp:associatedWith
|
gptkb:Li-Fraumeni_syndrome
Various cancers
|
|
gptkbp:biologicalProcess
|
DNA repair
Transcription regulation
Apoptosis
DNA-binding
Cell cycle arrest
Senescence
|
|
gptkbp:database
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:domain
|
DNA-binding domain
Tetramerization domain
Transactivation domain
|
|
gptkbp:Entrez_Gene_ID
|
7157
ENSG00000141510
|
|
gptkbp:evidence
|
Experimental protein level
|
|
gptkbp:function
|
Acts as a tumor suppressor in many tumor types
|
|
gptkbp:gene
|
gptkb:TP53
|
|
gptkbp:GO
|
GO:0005634
GO:0003677
GO:0003700
GO:0006355
|
|
gptkbp:hasIsoform
|
Multiple alternative splicing isoforms
|
|
gptkbp:HGNC_ID
|
11998
|
|
gptkbp:KEGGID
|
gptkb:hsa:7157
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:mass
|
43.7 kDa
|
|
gptkbp:mutationAssociatedWith
|
Frequently mutated in human cancers
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:2OCJ
gptkb:3KMD
gptkb:4HJE
1TUP
5XVK
|
|
gptkbp:postTranslationalModification
|
Methylation
Phosphorylation
Acetylation
Ubiquitination
Sumoylation
|
|
gptkbp:protein_name
|
gptkb:Cellular_tumor_antigen_p53
|
|
gptkbp:Reactome
|
gptkb:R-HSA-69563
|
|
gptkbp:refersTo
|
Human protein: Tumor protein p53
|
|
gptkbp:RefSeq
|
NP_000537.3
|
|
gptkbp:sequence
|
393
|
|
gptkbp:sequenceStatus
|
Complete
|
|
gptkbp:status
|
Reviewed
|
|
gptkbp:subcellularLocation
|
gptkb:Mitochondrion
gptkb:Nucleus
gptkb:Cytoplasm
|
|
gptkbp:taxonomicID
|
9606
|
|
gptkbp:UniGene
|
Hs.476226
|
|
gptkbp:UniProt_entry_name
|
gptkb:P53_HUMAN
|
|
gptkbp:bfsParent
|
gptkb:brain-derived_neurotrophic_factor
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P23560
|