|
gptkbp:instanceOf
|
gptkb:protein
tumor suppressor
|
|
gptkbp:activatedBy
|
gptkb:hypoxia
DNA damage
oncogenic stress
|
|
gptkbp:alias
|
gptkb:p53
gptkb:cellular_tumor_antigen_p53
|
|
gptkbp:category
|
transcription factor
DNA-binding protein
tumor suppressor gene product
|
|
gptkbp:decommissioned
|
mutant
viral proteins
MDM2 overexpression
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_Levine
gptkb:David_Lane
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:encodedBy
|
gptkb:TP53_gene
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
many vertebrates
|
|
gptkbp:function
|
DNA repair
regulation of cell cycle
senescence
apoptosis induction
genomic stability maintenance
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
tumor suppressor p53
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~53 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Li-Fraumeni_syndrome
|
|
gptkbp:negativelyRegulatedBy
|
gptkb:MDM2
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:phosphorylates
|
gptkb:ATR
gptkb:CHK2
ATM
CHK1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
gptkb:BAX
gptkb:GADD45
gptkb:NOXA
gptkb:PUMA
gptkb:p21
gptkb:MDM2
genes involved in DNA repair
genes involved in apoptosis
genes involved in cell cycle arrest
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:target
|
cancer research
therapeutic drugs
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:NP_005017.2
|
|
gptkbp:bfsLayer
|
6
|