|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:p53
|
|
gptkbp:alias
|
gptkb:CIP1
gptkb:WAF1
gptkb:MDA-6
gptkb:SDI1
|
|
gptkbp:associatedWith
|
gptkb:cancer
aging
cellular stress response
|
|
gptkbp:binds
|
gptkb:PCNA
|
|
gptkbp:discoveredBy
|
Xiong et al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:CDKN1A_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:CDKN1A
gptkb:ENSG00000124762
1026
|
|
gptkbp:expressedIn
|
many human tissues
|
|
gptkbp:function
|
cyclin-dependent kinase inhibitor
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:1784
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p21 (CDKN1A)
|
|
gptkbp:inhibitedBy
|
gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
gptkb:CDK1
|
|
gptkbp:involvedIn
|
apoptosis
cellular senescence
DNA damage response
tumor suppression
|
|
gptkbp:length
|
164 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
gptkb:6p21.2
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:OMIM
|
116899
|
|
gptkbp:orthologInMouse
|
gptkb:Cdkn1a
|
|
gptkbp:orthologInZebrafish
|
cdkn1a
|
|
gptkbp:PDB
|
gptkb:1AXC
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:proteinFamily
|
gptkb:CIP/KIP_family
|
|
gptkbp:regulates
|
gptkb:S_phase
transcription
DNA replication
cell cycle
G1 phase
|
|
gptkbp:structure
|
intrinsically disordered protein
|
|
gptkbp:UniProtID
|
gptkb:P38936
|
|
gptkbp:bfsParent
|
gptkb:TP53
|
|
gptkbp:bfsLayer
|
6
|