Epidermal Growth Factor Receptor signaling pathway

URI: https://gptkb.org/entity/Epidermal_Growth_Factor_Receptor_signaling_pathway
GPTKB entity
Statements (39)
Predicate Object
gptkbp:instanceOf biological pathway
gptkbp:activatedBy gptkb:PI3K-AKT_pathway
gptkb:PLCĪ³_pathway
gptkb:RAS-RAF-MEK-ERK_pathway
gptkb:JAK-STAT_pathway
gptkbp:alsoKnownAs gptkb:EGFR_signaling_pathway
gptkbp:component signal transduction
autophosphorylation
EGFR dimerization
adaptor protein recruitment
gptkbp:database gptkb:KEGG:_hsa04012
gptkb:Reactome:_R-HSA-177929
gptkbp:dysregulationAssociatedWith gptkb:non-small_cell_lung_cancer
gptkb:cancer
gptkb:glioblastoma
colorectal cancer
gptkbp:encodedBy gptkb:EGFR_gene
gptkbp:foundIn gptkb:human
gptkb:mouse
right
https://www.w3.org/2000/01/rdf-schema#label Epidermal Growth Factor Receptor signaling pathway
gptkbp:involves gptkb:EGF_ligand
gptkb:Epidermal_Growth_Factor_Receptor
tyrosine kinase activity
gptkbp:modulatedBy mutations in EGFR
EGFR inhibitors
amplification of EGFR
gptkbp:regulates apoptosis
cell differentiation
cell proliferation
cell survival
cell migration
gptkbp:target gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
gptkbp:bfsParent gptkb:EGFR_signaling_pathway
gptkbp:bfsLayer 6