Epidermal Growth Factor Receptor signaling pathway

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:biological_pathway
gptkbp:activatedBy	gptkb:PI3K-AKT_pathway gptkb:PLCγ_pathway gptkb:RAS-RAF-MEK-ERK_pathway gptkb:JAK-STAT_pathway
gptkbp:alsoKnownAs	gptkb:EGFR_signaling_pathway
gptkbp:component	signal transduction autophosphorylation EGFR dimerization adaptor protein recruitment
gptkbp:database	gptkb:KEGG:_hsa04012 gptkb:Reactome:_R-HSA-177929
gptkbp:dysregulationAssociatedWith	gptkb:non-small_cell_lung_cancer gptkb:cancer gptkb:glioblastoma colorectal cancer
gptkbp:encodedBy	gptkb:EGFR_gene
gptkbp:foundIn	gptkb:human gptkb:mouse gptkb:right
gptkbp:involves	gptkb:EGF_ligand gptkb:Epidermal_Growth_Factor_Receptor tyrosine kinase activity
gptkbp:modulatedBy	mutations in EGFR EGFR inhibitors amplification of EGFR
gptkbp:regulates	apoptosis cell differentiation cell proliferation cell survival cell migration
gptkbp:target	gptkb:afatinib gptkb:cetuximab gptkb:erlotinib gptkb:gefitinib gptkb:osimertinib
gptkbp:bfsParent	gptkb:EGFR_signaling_pathway
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	Epidermal Growth Factor Receptor signaling pathway