Statements (25)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
signaling molecule
|
| gptkbp:activatedBy |
gptkb:receptor_tyrosine_kinases
gptkb:protein_kinase_C_(PKC) growth factor receptors |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
autoimmune diseases |
| gptkbp:foundIn |
mammalian cells
|
| https://www.w3.org/2000/01/rdf-schema#label |
PLCγ pathway
|
| gptkbp:involves |
cell differentiation
cell proliferation cell migration immune cell signaling |
| gptkbp:involvesProtein |
gptkb:phospholipase_C_gamma_(PLCγ)
|
| gptkbp:launched |
phosphorylation of PLCγ
|
| gptkbp:leads_to_production_of |
gptkb:diacylglycerol_(DAG)
gptkb:inositol_1,4,5-trisphosphate_(IP3) |
| gptkbp:modulatedBy |
gene expression
|
| gptkbp:PLCγ_binds_to |
phosphotyrosine residues on activated receptors
|
| gptkbp:PLCγ_contains_domain |
SH2 domain
SH3 domain |
| gptkbp:result |
release of intracellular calcium
|
| gptkbp:bfsParent |
gptkb:PDGFR
gptkb:VEGF_signaling_pathway gptkb:EGFR_signaling_pathway |
| gptkbp:bfsLayer |
6
|