|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
GTP-bound
growth factor receptors
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alias
|
gptkb:Ras_gene_family
gptkb:Ras_proto-oncogene_family
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:database
|
gptkb:HGNC:9873
gptkb:UniProt:P01112
GeneCards:RAS
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:downstreamOf
|
gptkb:PI3K
gptkb:RAF_kinase
gptkb:RalGDS
|
|
gptkbp:encodes
|
small GTPase proteins
|
|
gptkbp:firstDescribed
|
1982
|
|
gptkbp:foundIn
|
all eukaryotes
|
|
gptkbp:fullName
|
gptkb:Rat_Sarcoma
|
|
gptkbp:function
|
guanine nucleotide exchange factor
signal transduction
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAS
|
|
gptkbp:inactiveForm
|
GDP-bound
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkb:RalGEF_pathway
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11p15.5_(HRAS)
gptkb:chromosome_12p12.1_(KRAS)
gptkb:chromosome_1p13.2_(NRAS)
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:plasma_membrane
|
|
gptkbp:member
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
gptkbp:memberOf
|
gptkb:RAS_superfamily
|
|
gptkbp:molecularWeight
|
~21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
oncogenic
|
|
gptkbp:mutationCommonIn
|
gptkb:cancer
colorectal cancer
melanoma
pancreatic cancer
|
|
gptkbp:orthologIn
|
gptkb:C._elegans_let-60
gptkb:Drosophila_Ras85D
many eukaryotes
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
prenylation
|
|
gptkbp:proteinFamily
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
gptkbp:regulates
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
apoptosis
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:relatedTo
|
molecular switch
signal transduction protein
tumor suppressor
|
|
gptkbp:significance
|
target for cancer therapy
|
|
gptkbp:structure
|
small molecule
|
|
gptkbp:target
|
direct KRAS G12C inhibitors
farnesyltransferase inhibitors
|
|
gptkbp:bfsParent
|
gptkb:Royal_Astronomical_Society
|
|
gptkbp:bfsLayer
|
3
|
