|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:TGFα
|
|
gptkbp:binds
|
gptkb:epidermal_growth_factor_receptor
|
|
gptkbp:category
|
growth factor
signaling molecule
|
|
gptkbp:cleavage
|
soluble ligand
|
|
gptkbp:discoveredBy
|
gptkb:Mariano_Barbacid
|
|
gptkbp:discoveredIn
|
1980
|
|
gptkbp:encodedBy
|
gptkb:TGFA_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000163235
|
|
gptkbp:expressedIn
|
gptkb:keratinocytes
neurons
macrophages
epithelial cells
|
|
gptkbp:family
|
gptkb:EGF_family
|
|
gptkbp:fullName
|
gptkb:Transforming_Growth_Factor_alpha
|
|
gptkbp:function
|
cell proliferation
epithelial development
|
|
gptkbp:gene
|
gptkb:TGFA
|
|
gptkbp:HGNC_ID
|
11742
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TGF-alpha
|
|
gptkbp:involvedIn
|
tissue regeneration
embryogenesis
tumorigenesis
|
|
gptkbp:length
|
50 amino acids (mature form)
|
|
gptkbp:locatedOnChromosome
|
gptkb:human_chromosome_2p13
|
|
gptkbp:molecularWeight
|
5.6 kDa (mature form)
|
|
gptkbp:OMIM
|
190170
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:orthologIn
|
gptkb:EGF
|
|
gptkbp:PDB
|
gptkb:1MOX
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic cleavage
|
|
gptkbp:predecessor
|
transmembrane protein
|
|
gptkbp:promotion
|
cell differentiation
angiogenesis
cell growth
epithelial cell migration
fibroblast proliferation
|
|
gptkbp:recipient
|
gptkb:EGFR
|
|
gptkbp:RefSeq
|
gptkb:NP_003227
|
|
gptkbp:role
|
gptkb:cancer
wound healing
psoriasis
|
|
gptkbp:structure
|
single polypeptide chain
|
|
gptkbp:UniProtID
|
gptkb:P01135
|
|
gptkbp:bfsParent
|
gptkb:EGFR_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|