|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:HBEGF
gptkb:Heparin-binding_EGF-like_growth_factor
DTR
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
myocardial infarction
atherosclerosis
pre-eclampsia
|
|
gptkbp:binds
|
gptkb:EGFR
gptkb:ERBB4
|
|
gptkbp:cleavage
|
gptkb:ADAM_metalloproteases
|
|
gptkbp:discoveredBy
|
gptkb:Higashiyama_et_al.
|
|
gptkbp:encodedBy
|
gptkb:HBEGF_gene
|
|
gptkbp:Entrez_Gene_ID
|
1839
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
gptkb:placenta
gptkb:keratinocytes
heart
liver
pancreas
neurons
macrophages
endothelial cells
fibroblasts
smooth muscle
astrocytes
|
|
gptkbp:firstDescribed
|
1991
|
|
gptkbp:fullName
|
gptkb:Heparin-binding_EGF-like_growth_factor
|
|
gptkbp:function
|
growth factor
chemoattractant
mitogen
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HB-EGF
|
|
gptkbp:locatedOnChromosome
|
5q31-q32
|
|
gptkbp:location
|
gptkb:cell_membrane
extracellular space
|
|
gptkbp:memberOf
|
gptkb:EGF_family
|
|
gptkbp:molecularWeight
|
22 kDa (mature form)
|
|
gptkbp:OMIM
|
600183
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
1BQQ
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:predecessor
|
gptkb:proHB-EGF
|
|
gptkbp:RefSeq
|
NP_001915.2
|
|
gptkbp:role
|
wound healing
cancer progression
cardiac development
tissue repair
|
|
gptkbp:structure
|
contains EGF-like domain
contains heparin-binding domain
|
|
gptkbp:UniProtID
|
Q99075
|
|
gptkbp:bfsParent
|
gptkb:EGFR_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|